Here is something that is pretty neat:
The size and shape of the human cerebral cortex, an evolutionary marvel responsible for everything from Shakespeare’s poetry to the atomic bomb, are largely influenced by mutations in a single gene, according to a team of researchers led by the Yale School of Medicine and three other universities.
The researchers found that mutations in the same gene, centrosomal NDE1, which is involved in cell division, were responsible for the deformity.
“The degree of reduction in the size of the cerebral cortex and the effects on brain morphology suggest this gene plays a key role in the evolution of the human brain,” said Murat Gunel, co-senior author of the paper and the Nixdorff-German Professor of Neurosurgery and professor of genetics and neurobiology at Yale.
“These findings demonstrate how single molecules have influenced the expansion of the human cerebral cortex in the last five million years,” Gunel said.
So here is a gene, Nde1, that has played a key role in the enlargement of the brain during human evolution. As the article notes, Nde1 is part of the centrosome, an organelle that functions to organize the microtubules throughout the cell. The function of Nde1 is not well characterized, but it is known to play a role in mitosis and neuron migration. So it makes sense that a crippled version of Nde1 might exhibit deficient levels of cell division and neuron migration, explaining the small brained phenotype.
So when did Nde1 arise?
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