Category Archives: outline

2010 Top Ten: Designing Evolution

I decided to list my top 10 favorite entries from 2010.  By looking back, it helps to confirm my suspicion that the hypothesis of front-loading/nudging evolution is not only reasonable and plausible (as no one has ever shown otherwise), but it is also a fruitful and productive hypothesis.  The ten entries are not ordered by any criteria, but instead roughly follow a chronological sequence.

So here they are……

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The Summer of Front-loading

It was a fun and productive summer:

1. I provided evidence to support the hypothesis that the origin of mitochondria was front-loaded and, in doing so, ran across a striking example of molecular convergence.  All of this helps us see how front-loading can guide the blind watchmaker.

How to Guide the Blind Watchmaker

Guiding the Blind Watchmaker again

More Evidence of Front-loading Mitochondria

2. I outlined some evidence showing it to be plausible that blood was front-loaded into single-celled life forms.

Front-loading Blood

3. I outlined a search for the last universal common ancestor of all life

The Hunt for LUCA

and provided evidence that this ancestral state was not much different from a modern day cell:

Protein Domains in LUCA

Genomes and LUCA

4. The hypothesis of front-loading led me to consider the ribosome as a vehicle for front-loading, which in turn, led me to successfully expect:

a. ribosomal proteins would have functions apart from protein translation:

Front-loading with ribosomes

Another Ribosomal Protein Moonlights

b. rRNA would actually code for protein sequence:

Buried Code

c. Permutations of ribosomal protein code would actually code for other proteins:

Digging Up More Buried Code with Ribosomal Protein S5

Using the Ribosome to Encode a Brain Protein

5. I provided more evidence that the genetic code is remarkably exceptional:

An Exceedingly Exceptional Code

6. I provided an example where the choice of amino acids helps to front-load life:


DM Outline IV

My continuing effort to organize blog entries into an outline so readers can better connect the dots (a consilience of clues).

A. Detecting Design

1. Science and Design

a. Outline the common definitions of ‘subjective’ and ‘objective.’

b. Identify problems with common definitions and propose George Cooper’s definition of objective that which can be measured by all parties who should obtain the same result given an appropriate range of accuracy.

c. Draw upon the wisdom of one the great biologists, Jacques Monod, to explain why science cannot determine whether or not life was designed.

d. Demonstrate how archeology and forensics fail to give us reason to think that science can determine whether or not life was designed.

e. Explain how most proponents and critics of design are likely to think alike on one issue – they will find it uncomfortable to acknowledge that science cannot determine whether or not life was designed.

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